Biological and distributional observations are presented for 166 species/subspecies of North American Cerambycidae representing 100 genera/subgenera in four subfamilies. New or confirmed records include 245 larval hosts, 39 distributions, 66 flower hosts, and 18 adult hosts. The male of Gaurotes thoracica (Haldeman) is described, the holotype deposition of Purpuricenus linsleyi Chemsak is clarified, and comments or corrections to previous literature records for several species are made.